Here is my setup, FWIW. I haven't experienced any issues with file locks. But my setup is marginally different.
I have two laptops, an iMac, a NAS and a couple of phones connected to Resilio.
The iMac has multiple users, Tom and Jerry (and more).
I keep the Tom user logged in at all times as my primary "Resilio server" - even when Jerry is logged in. On MacOS I find the overhead of Tom+Resilio to be pretty small. You don't need to do this, but it works for me.
Both user profiles on the iMac have Resilio Pro set up to sync Folder X with each other, as well as Folder X on the laptops and NAS.
In my case I connected an external drive to the iMac. I use it for many purposes, including for my duplicated Resilio folders (such as Jerry's copy of Folder X). This reduces disk loads if Resilio were trying to write large files simultaneously to /Users/Tom/FolderX and /Users/Jerry/FolderX on the same disk. If I use Folder X often then I simply keep a shortcut to it on my desktop and in Finder Favorites.
External drives are pretty cheap, and this works for me since the iMac is stationary. If you have Macbooks then the external drive option may not be suitable for you.
I also share folder X (and other folders) on the iMac between the Tom and Jerry user profiles using MacOS file sharing (System Preferences - -Sharing - File Sharing). This gives Jerry the option of accessing Folder X directly from Tom's profile even when logged in as Jerry. I get the higher performance of the Fusion drive, and Resilio doesn't care where I edit the file. But if you use it this way you really want to be sure that the Tom profile is running so that Resilio syncs Jerry's changes.
Sounds complicated, but it wasn't so hard to set up taking it one step at a time. The critical issue for me was whether Resilio would run happily in two instances for Tom and Jerry, while they were both logged in. And the answer (for the last year++) has been yes.
This is the basic setup. I've got a few more features to my specific situation (e.g. the NAS), but those are not likely important for what you are trying to do.